Tadasoft 40 Mg contains tadalafil 40 mg (a PDE-5 inhibitor). The dose that should be avoided depends on your health condition, other medicines, and whether the dose was prescribed for you. Tadasoft 40 Mg should be avoided in these situations: With nitrate medicines Avoid tadalafil with medicines such as nitroglycerin or isosorbide nitrates because the combination can cause a dangerous drop in blood pressure. With other ED medicines Do not combine Tadasoft 40 Mg with sildenafil, vardenafil, avanafil, or other PDE-5 inhibitors unless specifically directed by a doctor. With certain heart conditions Men with unstable heart disease, very low blood pressure, or those advised to avoid ***** activity should not use higher tadalafil doses without medical evaluation. With certain interacting medicines Dose adjustments or avoidance may be needed with medicines such as some strong CYP3A inhibitors (for example, certain antifungal or HIV medicines). If you experience serious side effects Stop use and seek medical advice for chest pain, sudden vision or hearing changes, or an erection lasting more than 4 hours. A 40 mg tadalafil dose is a higher-strength dose, so it should only be taken when recommended by a healthcare professional. Many men are started on lower tadalafil strengths depending on their needs and tolerance. If you share your age, reason for using Tadasoft 40 Mg (ED or another condition), and any medicines you take, I can explain which risks apply to you.