Avana 100 mg safe for diabetic men? It can be safe for some men with diabetes, provided a doctor confirms it is suitable for them. Avana 100 mg generally contains avanafil, which treats erectile dysfunction. Diabetes itself is not an automatic reason to avoid it, but associated heart disease and other medicines can affect safety. AVANAFIL tablet +1 Important precautions Do not take it with nitrate medicines such as nitroglycerin or isosorbide; the combination can dangerously lower blood pressure. Check with your doctor if you have heart disease, low blood pressure, or kidney or liver problems. Possible side effects include headache, flushing, nasal congestion and back pain. Do not combine it with Tadarise, Tadasoft, sildenafil or other erectile dysfunction medicines unless specifically directed by your doctor. Seek emergency care for an erection lasting more than four hours or sudden loss of vision or hearing. DailyMed +1 Let me clarify three things so I can guide you more safely. How old are you? How long have you had diabetes, and is your blood sugar generally controlled? Do you take any heart or blood-pressure medicines, or medicines for diabetes? These details help determine whether Avana 100 mg may be appropriate for you.