Cenforce 150 mg, which contains Sildenafil citrate, can potentially affect liver function, especially in individuals with pre-existing liver conditions or when taken in higher doses. Here’s a clear breakdown: How Sildenafil and the Liver Are Related Sildenafil is metabolized primarily in the liver via the CYP3A4 enzyme system. In people with normal liver function, this metabolism usually proceeds safely. High doses like 150 mg (higher than standard 50–100 mg) can increase the liver’s workload, potentially raising liver enzyme levels temporarily. Potential Risks People with chronic liver disease, cirrhosis, or hepatitis may experience slower metabolism, leading to higher blood levels and increased risk of side effects. Rarely, high doses of Sildenafil have been associated with mild, transient increases in liver enzymes (ALT, AST). Severe liver injury from Sildenafil is very uncommon but can occur if combined with other hepatotoxic drugs or alcohol. Safety Recommendations Liver function tests are advised if you have liver disease or plan to take high doses like 150 mg. Always follow medical guidance; the usual max dose recommended by most physicians is 100 mg, so 150 mg is above standard and should be used only under supervision. Watch for symptoms like yellowing of skin/eyes (jaundice), dark urine, or unusual fatigue, which may indicate liver stress.