Avana 100 mg safe for people with diabetes? It can be safe for some men with diabetes, provided a doctor confirms it is suitable for them. Avana 100 mg usually contains avanafil, a medicine for erectile dysfunction. Clinical trials have studied avanafil in men with type 1 and type 2 diabetes. AVANAFIL tablet +1 Before taking it, consider these precautions: Heart health: Diabetes increases the risk of cardiovascular disease. Your doctor should assess whether ***** activity and treatment are safe for you. Blood pressure: Avanafil can lower blood pressure, particularly with certain blood pressure medicines or substantial alcohol consumption. Drug interactions: Never take it with nitrate medicines such as nitroglycerin or isosorbide. Certain other medicines can also make avanafil unsafe. Dose: 100 mg is a standard starting dose for many adults, but it should be used only as prescribed and no more than once in 24 hours. AVANAFIL tablet +1 Seek emergency care for chest pain, sudden vision or hearing loss, or an erection lasting four hours or longer.