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Malegra 100 is a medication commonly used to treat erectile dysfunction (ED) in men. Malegra 100 should be taken as directed by your healthcare provider. It's typically taken about 30 minutes to 1 hour before anticipated physical activity. It can be taken with or without food, although high-fat meals may delay the onset of action. It's important not to exceed the recommended dosage or take more than one dose in a 24-hour period unless advised by your healthcare provider.