Avanafil (sold in some places as Avana 100 mg) can affect blood pressure fairly quickly after you take it, because it works on blood vessels. When it can affect blood pressure Avanafil can start lowering blood pressure: Within 15–30 minutes after taking it (this is when it starts working) Peak effect around 30–60 minutes Blood pressure effects are usually mild in healthy people, but more noticeable if combined with other drugs Why it affects blood pressure It blocks the PDE5 enzyme, which increases nitric oxide effects → relaxes blood vessels → vasodilation → can cause a temporary drop in blood pressure. When the BP drop can become significant (important) The risk becomes higher if you: Take nitrates (like nitroglycerin for chest pain) → can cause a dangerous BP drop Use alpha-blockers (for prostate or BP) Drink alcohol in large amounts Already have low blood pressure or dehydration Have certain heart conditions How long the effect lasts Blood pressure effects generally last a few hours, aligning with its action window (about 4–6 hours total duration in most people) Warning signs to watch for Seek help if you get: Severe dizziness or fainting Chest pain Blurred vision with weakness Feeling like you might pass out If you want, tell me what other medicines you’re taking—I can check whether your combination increases blood pressure risk.