Malegra Oral Jelly contains Sildenafil, and several medicines can interact with it. Some interactions can cause a dangerous drop in blood pressure, while others can increase sildenafil levels in the body and raise the risk of side effects. Medicines That Should Not Be Taken With Malegra Oral Jelly Nitrate medications (major interaction) Nitroglycerin Isosorbide Mononitrate Isosorbide Dinitrate Combining sildenafil with nitrates can cause a severe and potentially life-threatening drop in blood pressure. Other Important Interactions Guanylate cyclase stimulators Riociguat This combination is contraindicated because it can cause excessive blood pressure lowering. Alpha-blockers Tamsulosin Doxazosin Alfuzosin Using these medicines together may increase the risk of dizziness, fainting, and low blood pressure. Blood pressure medications Amlodipine Lisinopril Losartan Metoprolol These may have additive blood-pressure-lowering effects when combined with sildenafil. Medicines That Increase Sildenafil Levels The following drugs can increase sildenafil concentrations and may require dose adjustments: Ritonavir Cobicistat Ketoconazole Itraconazole Clarithromycin Erythromycin Other Substances to Avoid Grapefruit or grapefruit juice Excessive alcohol Other ED medications such as Tadalafil or Vardenafil unless specifically directed by a healthcare professional. If you're taking any prescription medications and want to know whether they interact with Malegra Oral Jelly, tell me the names of the medicines and I can check them individually.