Cenforce 120 mg is a high-dose PDE5 inhibitor used for erectile dysfunction. Because the dose is strong, it is not safe for everyone, especially people with certain health conditions or medication use. People who should avoid high doses (like 120 mg): 1. Heart patients Those with recent heart attack or stroke People with unstable angina (chest pain at rest) Patients with severe heart failure or uncontrolled arrhythmia High doses may increase heart strain and cause dangerous blood pressure changes. 2. People taking nitrate medicines Drugs like nitroglycerin, isosorbide dinitrate/mononitrate Combination can cause a severe, life-threatening drop in blood pressure. 3. Patients with low blood pressure Already low BP can drop further, causing fainting or shock risk.